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Eric A. Hoffman, PhD

Director, Advanced Pulmonary Physiomic Imaging Laboratory: APPIL
Professor of Radiology - Division of Physiologic Imaging
Professor of Internal Medicine
Professor of Biomedical Engineering (BME)

Contact Information

Primary Office
C748 GH
Iowa City, IA 52242


BA, Physiological Psychology, Antioch College
PhD, Physiology, University of Minnesota / Mayo Graduate School of Medicine
Fellow, Physiology, Biodynamics Research Unit, Mayo Foundation, Rochester, MN
Fellow, Physiologic Imaging, Department of Physiology and Biophysics, Mayo Foundation, Rochester MN

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Informatics, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Cardiovascular Research Center, Environmental Health Sciences Research Center, Institute for Clinical and Translational Science, Iowa Institute for Biomedical Imaging

Research Summary

Dr. Eric A. Hoffman , Ph.D. is a professor of radiology, medicine and biomedical engineering at the University of Iowa. He is the director of the Advanced Pulmonary Physiomic Imaging Laboratory (APPIL) in the Department of Radiology and the director of the Iowa Comprehensive Lung Imaging Center (I-Clic) at the University of Iowa. He received his Ph.D. in Physiology from the University of Minnesota / Mayo Graduate School of Medicine in 1981 and remained on staff at the Mayo Clinic where he was a member of the team which Developed the Dynamic Spatial Reconstructor (DSR), a one of a kind CT scanner which was able to gather up to 240 contiguous CT sections of the body every 1/60 second. Throughout his career he has used advanced imaging methodologies to study basic respiratory physiology centered largely on mechanisms of ventilation and perfusion heterogeneity and regional lung mechanics. Dr. Hoffman moved from the Mayo Clinic in 1987 to head the Cardiothoracic Imaging Research Center in the Department of Radiology at the University of Pennsylvania and then moved in 1992 to his current position at the University of Iowa. Most recently, in addition to continuing basic physiologic research of the lung, he has begun to apply single and multi-spectral multidetector row spiral CT imaging methodology to objectively follow human lung pathology and pathophysiology with a particular emphasis on inflammatory lung diseases. Dr. Hoffman is the author of more than 375 journal articles and 20 book chapters in the field of dynamic volumetric imaging of the lung and heart and served for 5 years as the founding chair of the Physiology and Function from Multidimensional Imaging sessions of the SPIE Medical Imaging conference. Dr. Hoffman was inducted into the college of fellows of the American Institute for Medical and Biological Engineering in March of 2000 and was elected into the Fleischner Society in May 2005. He is currently the principal investigator on an NIH sponsored Biomedical Engineering Partnership Grant in which researchers have joined to build a computer-based model of the normal human lung based upon all the parameters that can be assessed by high speed multi-slice spiral CT. He is PI on several additional NIH funded grants aimed at studying normal and pathophysiology of the lung via CT imaging and his laboratory serves as the image archive and analysis center of several NIH sponsored multi-center studies including SPIROMICS, the Severe Asthma Research Project (SARP), COPDGene, and MESA-Lung (an extension of the multi ethnic study of atherosclerosis). As part of the Bioengineering Research Partnership grant, Dr. Hoffman's laboratory has, as a centerpiece, a research dedicated state-of-the-art multi-spectral, multi-detector row spiral CT (MDCT) scanner and an in vivo micro CT scanner. Through a relationship with Siemen's Medical, the MDCT scanner has remained at state-of-the-art to promote novel new lung imaging developments.