Congratulations to those in the Department who recently received new grants. Some of the new grants are listed below.

• Two faculty received pilot grants from the Hawk-IDDRC for $20,000/each:
  • Stephanie Lee, MD (Neonatology), who will be researching the impact of a common heart condition in very preterm infants on brain maturation
  • Kelly Schieltz, PhD (DBP), who will consider the feasibility of a brain imaging tool to study disruptive behavior in young children with intellectual and developmental disabilities.
• Aaron Boes, MD, PhD in the Division of Neurology
  • "Seizures and Children’s Outcomes After Stroke"
  • UCSF
  • $535,000
• Katie Larson Ode, MD in the Division of Endocrinology and Diabetes
  • 2021-2022 Diabetes Research Center Collaborative Pilot and Feasibility Grant Award
  • Institute for Diabetes, Obesity and Metabolism (IDOM) at the University of Minnesota and the Fraternal Order of Eagles Diabetes Research Center (FOEDRC) at the University of Iowa 
  • $70,000 
• Anthony Fischer, MD, PhD in the Division of Pulmonary Medicine
  • "Genomic analysis of Staphylococcus aureus persistence in Cystic Fibrosis"
  • Cystic Fibrosis Foundation
  • Provides $280,000 over 2 years
• Damian Krysan, MD, PhD in the Division of Infectious Diseases
  • "Discovery and Development fo Antifungal Acetyl CoA Synthetase Inhibitors"
  • NIH/R01
  • Providers just under $600,000 over 5 years
• Congratulations to the following individuals who received Stead Research, Chihldren's Miracle Network, or Dance Marathon grant awards recently
  • Stead Research Award
    • Aaron Boes, MD, PhD for his project "Investigating Cognitive Outcomes of Pediatric Ischemic Stroke" - $42,500
  • Dance Marathon Awards
    • David Gordon, MD, PhD for his project "Targeting ID2 in Sarcomas Using the Repurposed Drug Homoharringtonine" - $50,000
    • Gina Bardi Lola, MD (hem/onc fellow) for his project "Predicting Posterior Fossa Syndrome" - $50,000
  • Children's Miracle Network/SFCH Discretionary Awards
    • Polly Ferguson, MD for her project "Role of Fat Metabolism in Auto Inflammatory Bone Disease" - $50,000
    • Prashob Porayette, MD for his project "Influence of Hormonal Milieu on Fetal Brain Growth in Congenital Heart Disease" - $50,000
    • Bassel Mohammad Nijres, MD for his project "Single Stent for Stage I Palliation: Pilot Piglet Study" - $50,000
    • Oriana Vanegas Calderon, MD (GI fellow) for  her project "A Porcine-derived Pancrease aOrganoid Model to Study Cystic Fibrosis-related Pancreatic Disease" - $20,000
    • Gopinathan Gangadharan Nambiar, MD (GI fellow) for his project "Enzymatic Lysis of Meconium in Cystic Fibrosis Pigs" - $30,000
• Damian Krysan, MD, PhD in the Division of Infectious Diseases
  • Hit-to-lead Optimization of Broad Spectrum Antifungal Phenothiazines
  • NIH
  • Provides $434,000 over 2 years
• Tope Awelewa, MB, BCh, MPH in the Division of General Pediatrics and Adolescent Medicine
  • BreastFeed Iowa Black Immigrant (BIBI) Partnership
  • American Academy of Pediatrics / CATCH Implementation Grant
  • $10,000
• Andrew Norris, MD, PhD, from the Division of Endocrinology and Diabetes, along with Dr. John Engelhardt from Anatomy and Cell Biology (dual PI's).
  • Early Pathogenesis of Cystic Fibrosis Related Diabetes
  • NIH - RC2
  • Providers just over $4.45 million over 3 years.
• Jennifer Bermick, MD from the Division of Neonatology
  • Understanding the role of histone 3 lysine 4 trimethylation in neonatal innate immune development under normal and inflammatory conditions
  • NIH - R01
  • Provides just over $1.5 million over 4 years.
• Lyndsay Harshman, MD from the Division of Nephrology, Dialysis, and Transplantation, along with Dr. Elizabeth Chrischilles in the College of Public Health
  • Preserving Kidney Function in Children with Chronic Disease
  • Patient-Centered Outcomes Research Institute (PCORI) / Children's Hospital of Philadelphia
  • Provides $5 million over 3 years.
  • UI will be one of 18 centers across the country participating
• Neeraja Swaminathan, MD (research fellow), from the Division of Hematology/Oncology
  • Mentor: Dr. Anjali Sharathkumar
  • Elucidating the age-dependent variation of clinical and laboratory phenotype of hemophilia carriers along with prescription trends of hemostatic therapies - Analysis of the ATHNdataset
  • Hemostasis and Thrombosis Research Society, Inc. (“HTRS”) and the American Thrombosis and Hemostasis Network (“ATHN”)
  • Provides $60,000 for one year, with the possibility of extension
• Dr. Janice Staber from the Division of Hematology/Oncology
  • Platelet Activation in Cystic Fibrosis
  • Cystic Fibrosis Foundation
  • Provides $112,000 over 2 years
• Beth Newell, MD from the Division of Critical Care
  • Junior RPOE Award
  • Iowa Neuroscience Institute/Carver Trust
  • $150,000/year for two years, beginning July 1, 2021
• Jessica Zimmerman, MD from the Division of Hematology/Oncology
  • Understanding idelalisib-induced glucocorticoid potentiation in high-risk B-cell acute lymphoblastic leukemia
  • Holden Comprehensive Cancer Center (UIHC)
  • $10,000
• Damian Krysan, MD, PhD from the Division of Infectious Diseases
  • Systematic in vitro and in vivo genetic analysis of C. albians protein kinases
  • Sponsor: NIH
  • Provides $435,944 over 2 years
• David Gordon, MD, PhD from the Division of Hematology/Oncology
  • Sarcoma P01 Support
  • Sponsor: Holden Comprehensive Cancer Center
  • $53,282
• Patrick Sinn, PhD from the Division of Pulmonary Medicine
  • Intercellular Transfer of Cytoplasm and Measles Virus Through Nectins
  • Sponsor: Mayo Clinic/NIH
  • Provides $358,268 over 4 years
• Elizabeth Newell, MD from the Division of Critical Care
  • Targeting the microglial response following pediatric traumatic brain injury
  • Sponsor: Iowa Neuroscience Institute
  • $50,000
  • Dr. Newell seeks to identify age-dependent and cell-specific mechanisms of chronic neurodegeneration following pediatric traumatic brain injury (TBI). Annually, 500,000 children suffer from TBI resulting in 7,000 TBI-related deaths. There are no pharmacologic therapies for TBI. Due to the significant brain maturation that occurs across childhood and adolescence, an improved understanding of age-dependent secondary injury responses is necessary for effective therapy development. The goal of this project is to identify age-dependent alterations in microglial reactivity that impact brain recovery and represent therapeutic targets. As TBI is a leading cause of pediatric death and disability, translation of this research has the potential to dramatically impact childhood health
• Paul McCray, MD from the Division of Pulmonary Medicine
  • A team of cystic fibrosis experts with University of Iowa Health Care, led by Dr. Paul McCray from the Division of Pulmonary Medicine, has been awarded a grant to research molecular therapies for cystic fibrosis (CF) lung disease.
  • Sponsor: National Heart, Lung, and Blood Institute
  • Provides $11.5 million over 5 years
• Kelly Schieltz, PhD and Matt O’Brien, PhD (co-PI’s), from Developmental and Behavioral Pediatrics
  • Interdisciplinary Training Project in Special Education and School Psychology
  • Sponsor: US Department of Education/Office of Special Education
  • Provides just over $1.5 million over 5 years
  • A training grant where all objectives are focused on the outcomes of the graduate students. The focus of the training is to prepare students in intensive interventions and assessment for school-aged children with disabilities who have high intensity needs.”
• Charles Grose, MD (ID)
  • Vascular Effects of Infection in Pediatric Stroke (VIPSII) Study
  • Sponsor: NIH/University of California, San Francisco
  • $75,000 over 2 years
• Joseph Glykys, MD, PhD (Neurology)
  • R01: Water and chloride movement in neurons during seizure activity
  • Sponsor: NIH
  • Provides just over $2.1 million over 5 years